Apolipoproteins are proteins that have binding affinity for lipids to form packages called lipoproteins. They are responsible for transporting lipids through the lymphatic and circulatory systems. The APOE gene encodes the Apolipoprotein E protein, which is a major component of chylomicrons and VLDLs (Very Low-Density Lipoproteins). They are mainly involved in packaging and transporting cholesterol [...]

Type III hyperlipoproteinemia is a genetic disorder characterized by high blood cholesterol and triglycerides, leading to atherosclerosis and cardiovascular disease. Signs and symptoms of Type III hyperlipoproteinemia vary in severity. The symptoms for this disorder do not typically appear unless triggered by dietary, hormonal and metabolic factors. These factors can contribute to elevated blood lipid [...]

Atherosclerosis is a condition where plaque progressively builds up in the arteries over time, causing narrowing and hardening of the arteries. Excess LDL cholesterol in the bloodstream accumulates as plaque deposits which restrict or block oxygen supply to organs and other tissues, leading to serious problems such as cardiovascular disease. For example, if the oxygen [...]

Hyperlipoproteinemia, also known as hyperlipidemia, is a group of disorders characterized by abnormally elevated levels of lipids/lipoproteins in blood. Due to their water-insoluble properties, lipids combine with lipoproteins in order to be transported through the bloodstream. Elevated lipid and lipoprotein levels can predispose people to atherosclerosis, leading to increased risk of developing cardiovascular disease. There [...]